The Human Brain Connectome Weighted by the Myelin Content and Total Intra-Axonal Cross-Sectional Area of White Matter Tracts

Abstract A central goal in neuroscience is the development of a comprehensive mapping between structural and functional brain features which facilitates mechanistic interpretation function. However, interpretability structure-function models remains limited by lack biological detail. Here, we characterize human networks weighted multiple white matter microstructural including total intra-axonal cross-sectional area myelin content. We report edge-weight-dependent spatial distributions, variance, small-worldness, rich club, hubs, as well relationships with function, edge length myelin. Contrasting content tracts, find opposite connectivity, an edge-length-independent inverse relationship each other, canonical club myelin-weighted networks. When controlling for length, either fractional anisotropy, radial diffusivity or neurite density show no whole-brain connectivity. conclude that co-utilization could improve our understanding mechanisms mediating relationship.